Patients are encouraged to speak with their GP or a specialist weight management service about the most appropriate treatment for their individual circumstances
Available from: Accessed 28 June 2025 Kindel TL, Wang AY, Wadhwa A, et al
The key findings relevant to this question: No clinically relevant drug-metabolizing enzyme-mediated interactions have been reported for GLP-1 agonists Some transporters (OATP1B1/3, OAT3) showed inhibition with GLP-1 agonist treatment in vitro Significant changes in oral contraceptive and levothyroxine absorption were documented with tirzepatide and oral semaglutide GLP-1 agonists delay gastric emptying, which can alter absorption of co-administered oral medications Critically, no published study has examined the drug-drug interaction profile of two injectable GLP-1 agonists administered concurrently
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Always coordinate medication changes, such as starting or stopping Ozempic, with your prescribing physician