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The article's risk table lists a history of delayed gastric emptying as a pre-existing condition that may amplify semaglutide's effect on stomach transit, and says it requires individualized assessment

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He M, Ma Y, Wang R, Zhang J, Jing L, Li PA (2020) Deletion of mitochondrial uncoupling protein 2 exacerbates mitochondrial damage in mice subjected to cerebral ischemia and reperfusion injury under both normo- and hyperglycemic conditions

Phase 2 Clinical Trial Data The landmark Phase 2 trial of retatrutide in obesity was a 48-week, randomized, double-blind, placebo-controlled study published in The New England Journal of Medicine in 2023