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GLP-1 receptors in the hypothalamus and brainstem mediate appetite suppression and satiety, contributing to weight loss through reduced caloric intake
As a surrogate for peptide integrity, the activity of the fusion molecule was assessed by its ability to activate human GLP-1R in an ex vivo bioassay
Additionally, GLP-1 reduces the release of glucagon, another hormone produced by the pancreas, which typically signals the liver to release stored glucose
Detailed in vitro characterisation of monotreme GLP-1 peptides revealed evolutionary signatures that can be explained by selective conflict as a result of the recruitment of this molecule into venom
