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GLP-1 receptor agonists mimic natural hormones to enhance insulin secretion, suppress glucagon, slow gastric emptying and reduce appetite for diabetes and weight management
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The search included combinations of the following terms: tirzepatide, GIP receptor agonist, GLP-1 receptor agonist, gut microbiota, obesity, metabolites, inflammation, and host metabolism. Additional relevant articles were identified through manual screening of reference lists from selected publications
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Similarly, exenatide ameliorated the inflammatory response in human RA FLSs by decreasing the oxidative stress capacity of FLSs and down-regulating the expression of IL-1 and IL-6, while suppressing the initiation of p38/MAPK and NF-B signal transduction pathways [240]
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