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What that looks like in practice: some people notice shifts in energy and how their body composition responds before the scale moves much, since the goal is metabolic, not just water weight

Finally, the biggest risk is for people who have pernicious anemia, a rare condition in which a person is unable to absorb any B12 through their stomach or intestines people with this condition are the ones who actually need B12 injections

As noted, the present knowledge is limited, and these are considerations, not strong recommendations

If a rash spreads or comes with swelling, see a dermatologist

Angiogenic signaling pathways and anti-angiogenic therapy for cancer